TOBI PODHALER is for people 6 years and older with cystic fibrosis (CF), Pseudomonas aeruginosa (Pa), and forced expiratory volume in 1 second (FEV1) 25% to 80% predicted and who do not have Burkholderia cepacia.
TOBI PODHALER demonstrated 12.54% improvement in FEV1% predicted after 28 days of treatment compared with 0.09% improvement with placebo.
In another study, TOBI PODHALER did not show significant improvements in lung function compared with placebo.
in a clinical trial of TOBI vs. placebo
4.4% of patients who received TOBI PODHALER required respiratory-related hospitalizations during the course of 1 treatment cycle vs. 12.2% of patients who received placebo.
in a clinical trial of TOBI vs. placebo
8.7% of patients who received TOBI PODHALER used IV antipseudomonal antibiotics during the course of 1 treatment cycle vs. 10.2% of patients who received placebo.
It is not known if TOBI PODHALER is safe and effective when used for more than 3 cycles.
Laboratory test results show reduced tobramycin activity against Pa bacteria in some patients with the use of TOBI PODHALER. The relationship between these lab results and how well TOBI PODHALER works is not clear. Let your healthcare provider know if your symptoms worsen.
Click here to learn more about the Safety Information.
*In this randomized, double-blind study, patients with cystic fibrosis (age 6–21 years) received treatment with TOBI PODHALER (112 mg tobramycin) twice daily (n=46) or placebo (n=49) via the T-326 Inhaler for one cycle, followed by two open-label cycles (all patients). The total study duration was 24 weeks.
†Lung function is measured by forced expiratory volume in 1 second (FEV1), or the amount of air you can blow out in 1 second after taking a deep breath. After FEV1 is measured, it is expressed as a percentage of the predicted normal FEV1 value for the patient, or FEV1% predicted.
TOBI® PODHALER® (Tobramycin Inhalation Powder) 28 mg per capsule is a prescription inhaled medication for cystic fibrosis patients whose lungs contain bacteria called Pseudomonas aeruginosa.
It is not known if TOBI PODHALER is safe and effective in patients under 6 years of age, in those with lung function outside of a certain range, or in those whose lungs contain bacteria called Burkholderia cepacia.
Do not swallow TOBI PODHALER capsules. TOBI PODHALER capsules are used only with the Podhaler device and inhaled through your mouth (oral inhalation). Never place a capsule in the mouthpiece of the Podhaler device.
You should not use TOBI PODHALER if you are allergic to it or to any other aminoglycoside antibacterial medicines.
Tell your doctor before starting treatment all of your medical conditions, including if you have or have had hearing problems, dizziness, kidney problems, muscle weakness, breathing problems such as wheezing, coughing or chest tightness, if you had an organ transplant, are pregnant or nursing or plan to become pregnant or nurse.
TOBI PODHALER contains a medicine that can harm your unborn baby. It is not known if it passes into breast milk. Check your baby for watery stools, bloody stools, thrush or diaper rash if you breast feed.
Tell your doctor about all the medicines you take including over-the-counter medicines, vitamins, and herbal supplements. If you are using TOBI PODHALER, discuss if you should take other medicines that may harm your nervous system, kidneys, or hearing; "water pills" (diuretics) such as EDECRIN® (ethacrynic acid), LASIX® (furosemide), or intravenous mannitol; urea.
TOBI PODHALER can cause serious side effects, including:
Severe breathing problems (bronchospasm). Tell your doctor right away if you get shortness of breath with wheezing or coughing and chest tightness while using TOBI PODHALER.
Hearing loss or ringing in the ears (ototoxicity). Tell your doctor right away if you have hearing loss, noises in your ears such as ringing or hissing, vertigo, difficulty with balance, dizziness, or your mother has had hearing problems after taking an aminoglycoside. Tell your doctor if you have been told you have certain gene variants (a change in the gene) related to hearing abnormalities inherited from your mother.
Worsening kidney problems (nephrotoxicity). TOBI PODHALER is in a class of medicines that may cause worsening kidney problems, especially in people with known or suspected kidney problems. Your healthcare provider may do a blood test to check how your kidneys are working while you are using TOBI PODHALER.
Worsening muscle weakness. TOBI PODHALER is in a class of medicines that can cause worsening muscle weakness in people who already have problems with muscle weakness (myasthenia gravis or Parkinson's disease).
TOBI PODHALER is in a class of medicines which may cause harm to an unborn baby.
The most common side effects of TOBI PODHALER include cough, worsening of lung problems or cystic fibrosis, productive cough, shortness of breath, fever, sore throat, changes in your voice (hoarseness), coughing up blood, and headache.
Let your doctor know if your symptoms worsen or if you have a side effect that bothers you enough to stop treatment or that does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call
1-800-FDA-1088.
Please see Full Prescribing Information and Patient Information.
TOBI® PODHALER® (Tobramycin Inhalation Powder) 28 mg per capsule is a prescription inhaled medication for cystic fibrosis patients whose lungs contain bacteria called Pseudomonas aeruginosa.
It is not known if TOBI PODHALER is safe and effective in patients under 6 years of age, in those with lung function outside of a certain range, or in those whose lungs contain bacteria called Burkholderia cepacia.
Do not swallow TOBI PODHALER capsules. TOBI PODHALER capsules are used only with the Podhaler device and inhaled through your mouth (oral inhalation). Never place a capsule in the mouthpiece of the Podhaler device.
You should not use TOBI PODHALER if you are allergic to it or to any other aminoglycoside antibacterial medicines.
Tell your doctor before starting treatment all of your medical conditions, including if you have or have had hearing problems, dizziness, kidney problems, muscle weakness, breathing problems such as wheezing, coughing or chest tightness, if you had an organ transplant, are pregnant or nursing or plan to become pregnant or nurse.
TOBI PODHALER contains a medicine that can harm your unborn baby. It is not known if it passes into breast milk. Check your baby for watery stools, bloody stools, thrush or diaper rash if you breast feed.
Tell your doctor about all the medicines you take including over-the-counter medicines, vitamins, and herbal supplements. If you are using TOBI PODHALER, discuss if you should take other medicines that may harm your nervous system, kidneys, or hearing; "water pills" (diuretics) such as EDECRIN® (ethacrynic acid), LASIX® (furosemide), or intravenous mannitol; urea.
TOBI PODHALER can cause serious side effects, including:
Severe breathing problems (bronchospasm). Tell your doctor right away if you get shortness of breath with wheezing or coughing and chest tightness while using TOBI PODHALER.
Hearing loss or ringing in the ears (ototoxicity). Tell your doctor right away if you have hearing loss, noises in your ears such as ringing or hissing, vertigo, difficulty with balance, dizziness, or your mother has had hearing problems after taking an aminoglycoside. Tell your doctor if you have been told you have certain gene variants (a change in the gene) related to hearing abnormalities inherited from your mother.
Worsening kidney problems (nephrotoxicity). TOBI PODHALER is in a class of medicines that may cause worsening kidney problems, especially in people with known or suspected kidney problems. Your healthcare provider may do a blood test to check how your kidneys are working while you are using TOBI PODHALER.
Worsening muscle weakness. TOBI PODHALER is in a class of medicines that can cause worsening muscle weakness in people who already have problems with muscle weakness (myasthenia gravis or Parkinson's disease).
TOBI PODHALER is in a class of medicines which may cause harm to an unborn baby.
The most common side effects of TOBI PODHALER include cough, worsening of lung problems or cystic fibrosis, productive cough, shortness of breath, fever, sore throat, changes in your voice (hoarseness), coughing up blood, and headache.
Let your doctor know if your symptoms worsen or if you have a side effect that bothers you enough to stop treatment or that does not go away.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
Please see Full Prescribing Information and Patient Information.
