TOBI Podhaler is for people 6 years and older with cystic fibrosis (CF), Pseudomonas aeruginosa (Pa), and forced expiratory volume in 1 second (FEV1) 25% to 80% predicted and who do not have Burkholderia cepacia.

Dosing and helpful tips when using TOBI Podhaler

  • Your healthcare provider should show you or your caregiver how to use TOBI Podhaler before you use it for the first time

The recommended dosage of TOBI Podhaler

4 28-mg capsules for inhalation

2 times a day (AM and PM) in cycles of

28 days on and

28 days off

  • The powder from all 4 capsules must be inhaled to receive the full dose
  • Inhale 2 times from each capsule in order to empty it
  • Take each dose as close to 12 hours apart as possible and no less than 6 hours apart

Helpful tips

  • Practice with the TOBI Podhaler Inhalation Trainer
  • Do not press the button more than once, as the capsule may break into pieces
  • Tilt head back slightly when inhaling
  • Inhale with a single, deep breath. Practice may help to find the best speed for you
  • Sip water after administering each capsule

Important Dosing Considerations

  • TOBI Podhaler capsules must not be swallowed
  • Capsules are for use with the Podhaler device only
  • Capsules are for oral inhalation only
  • Each dose of 4 capsules should be taken as close to 12 hours apart as possible; each dose should not be taken less than 6 hours apart
  • Capsules should always be stored in the blister card; each capsule should only be removed IMMEDIATELY BEFORE USE
Loading the player...

Watch a summary video on how to use TOBI Podhaler.

Please see full Prescribing Information, including Patient Information, and full Instructions for Use.

IMPORTANT SAFETY INFORMATION

INDICATION

TOBI® Podhaler® (Tobramycin Inhalation Powder) 28 mg per capsule is a prescription inhaled medication for cystic fibrosis patients whose lungs contain bacteria called Pseudomonas aeruginosa.

It is not known if TOBI Podhaler is safe and effective in patients under 6 years of age, in those with lung function outside of a certain range, or in those whose lungs contain bacteria called Burkholderia cepacia.

IMPORTANT SAFETY INFORMATION

Do not swallow TOBI Podhaler capsules. TOBI Podhaler capsules are used only with the Podhaler device and inhaled through your mouth (oral inhalation). Never place a capsule in the mouthpiece of the Podhaler device.

You should not use TOBI Podhaler if you are allergic to it or to any other aminoglycoside antibacterial medicines.

Tell your doctor before starting treatment all of your medical conditions, including if you have or have had hearing problems, dizziness, kidney problems, muscle weakness, breathing problems such as wheezing, coughing or chest tightness, if you had an organ transplant, are pregnant or nursing or plan to become pregnant or nurse.

TOBI Podhaler contains a medicine that can harm your unborn baby. It is not known if it passes into breast milk. Check your baby for watery stools, bloody stools, thrush or diaper rash if you breast feed.

Tell your doctor about all the medicines you take including over-the-counter medicines, vitamins, and herbal supplements. If you are using TOBI Podhaler, discuss if you should take other medicines that may harm your nervous system, kidneys, or hearing; "water pills" (diuretics) such as Edecrin® (ethacrynic acid), Lasix® (furosemide), or intravenous mannitol; urea.

TOBI Podhaler can cause serious side effects, including:

Severe breathing problems (bronchospasm). Tell your doctor right away if you get shortness of breath with wheezing or coughing and chest tightness while using TOBI Podhaler.

Hearing loss or ringing in the ears (ototoxicity). Tell your doctor right away if you have hearing loss, noises in your ears such as ringing or hissing, vertigo, difficulty with balance, or dizziness.

Worsening kidney problems (nephrotoxicity). TOBI Podhaler is in a class of medicines that may cause worsening kidney problems, especially in people with known or suspected kidney problems. Your healthcare provider may do a blood test to check how your kidneys are working while you are using TOBI Podhaler.

Worsening muscle weakness. TOBI Podhaler is in a class of medicines that can cause worsening muscle weakness in people who already have problems with muscle weakness (myasthenia gravis or Parkinson's disease).

TOBI Podhaler is in a class of medicines which may cause harm to an unborn baby.

The most common side effects of TOBI Podhaler include cough, worsening of lung problems or cystic fibrosis, productive cough, shortness of breath, fever, sore throat, changes in your voice (hoarseness), coughing up blood, and headache.

Let your doctor know if your symptoms worsen or if you have a side effect that bothers you enough to stop treatment or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.