Glossary

Some of the terms on this site may be unfamiliar to you. Here is a glossary for your reference.

Antibiotic [an-ti-bi-ott-ik]

A drug that kills bacteria or slows bacterial growth. Antibiotics are often used to treat lung infections.

Bacteria [bak-teer-ee-uh] (sometimes referred to as "bacterium" in the singular)

Very small, single-celled organisms that can reproduce quickly and are capable of causing an infection.

Chronic lung infection

A lung infection that lasts for a long time.

FEV1

Forced expiratory volume in 1 second (FEV1), or the amount of air you can blow out in 1 second. FEV1 is used to measure lung function.

Genetic [je-ne-tik]

Inherited from your parents through their genes.

Inhalation [in-hale-ay-shun]

The breathing in of an airborne substance that may be in the form of a gas, mist, vapor, powder, or aerosol.

Lung function [luhng fuhngk-shun]

When evaluating efficacy of TOBI Podhaler, measured by FEV1. After FEV1 is measured, it is expressed as a percentage of the predicted normal FEV1 value for the patient, or FEV1% predicted.

Mucus [myu-kus]

A slippery substance secreted by cells and glands in the mucous membrane. People with cystic fibrosis produce thicker mucus than healthy people do, which can clog their lungs.

Nebulizer [neb-u-lye-zer]

A device for creating and administering an aerosol spray.

Off-cycle

Following the on-cycle, the 28 days when you are off treatment.

On-cycle

The 28 days when you are on treatment.

Pseudomonas aeruginosa (soo-doh-MOH-nass ah-ru-ji-NOH-sa)

A type of bacteria that can cause lung infections in people with cystic fibrosis. Pa is the abbreviation.

PulmoSphere® [pul-moh-sfeere]

Developed by Novartis Pharmaceuticals Corporation, PulmoSphere particles allow the necessary amount of antibiotic to be delivered in a dry-powder form.

IMPORTANT SAFETY INFORMATION

INDICATION

TOBI® Podhaler® (Tobramycin Inhalation Powder) 28 mg per capsule is a prescription inhaled medication for cystic fibrosis patients whose lungs contain bacteria called Pseudomonas aeruginosa.

It is not known if TOBI Podhaler is safe and effective in patients under 6 years of age, in those with lung function outside of a certain range, or in those whose lungs contain bacteria called Burkholderia cepacia.

IMPORTANT SAFETY INFORMATION

Do not swallow TOBI Podhaler capsules. TOBI Podhaler capsules are used only with the Podhaler device and inhaled through your mouth (oral inhalation). Never place a capsule in the mouthpiece of the Podhaler device.

You should not use TOBI Podhaler if you are allergic to it or to any other aminoglycoside antibacterial medicines.

Tell your doctor before starting treatment all of your medical conditions, including if you have or have had hearing problems, dizziness, kidney problems, muscle weakness, breathing problems such as wheezing, coughing or chest tightness, if you had an organ transplant, are pregnant or nursing or plan to become pregnant or nurse.

TOBI Podhaler contains a medicine that can harm your unborn baby. It is not known if it passes into breast milk. Check your baby for watery stools, bloody stools, thrush or diaper rash if you breast feed.

Tell your doctor about all the medicines you take including over-the-counter medicines, vitamins, and herbal supplements. If you are using TOBI Podhaler, discuss if you should take other medicines that may harm your nervous system, kidneys, or hearing; "water pills" (diuretics) such as Edecrin® (ethacrynic acid), Lasix® (furosemide), or intravenous mannitol; urea.

TOBI Podhaler can cause serious side effects, including:

Severe breathing problems (bronchospasm). Tell your doctor right away if you get shortness of breath with wheezing or coughing and chest tightness while using TOBI Podhaler.

Hearing loss or ringing in the ears (ototoxicity). Tell your doctor right away if you have hearing loss, noises in your ears such as ringing or hissing, vertigo, difficulty with balance, or dizziness.

Worsening kidney problems (nephrotoxicity). TOBI Podhaler is in a class of medicines that may cause worsening kidney problems, especially in people with known or suspected kidney problems. Your healthcare provider may do a blood test to check how your kidneys are working while you are using TOBI Podhaler.

Worsening muscle weakness. TOBI Podhaler is in a class of medicines that can cause worsening muscle weakness in people who already have problems with muscle weakness (myasthenia gravis or Parkinson's disease).

TOBI Podhaler is in a class of medicines which may cause harm to an unborn baby.

The most common side effects of TOBI Podhaler include cough, worsening of lung problems or cystic fibrosis, productive cough, shortness of breath, fever, sore throat, changes in your voice (hoarseness), coughing up blood, and headache.

Let your doctor know if your symptoms worsen or if you have a side effect that bothers you enough to stop treatment or that does not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.